Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer
Abstract FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies.Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevalence of 35%.However, despite the frequent recurrence of FOXA1 mutations in prostate cancer, the mechan